Anti-platelet aggregation

Anemarsaponin B
Catalog No: CFN99532

Anemarsaponin B can inhibit PAF-induced rabbit platelet aggregation in vitro. Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway.

Hispidulin
Catalog No: CFN99491

Hispidulin has anti-oxidative, anti-inflammatory, anti-cancer, antiepileptic, neuroprotective, anti-osteoporotic and bone resorption attenuating effects, it targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1.

Proanthocyanidins
Catalog No: CFN99556

Proanthocyanidins exerts antiviral, hepatoprotective, cardioprotective, hypolipidemic, anti-osteoporosis, anti-inflammatory ,antioxidant and anti-apoptosis activities. Dietary proanthocyanidins inhibits photocarcinogenesis in mice through the inhibition of UVB-induced inflammation and mediators of inflammation in mouse skin. Proanthocyanidins form stable complexes with metal ions and with proteins and are good reducing agents, they may participate in the prevention of cancers, both of the digestive tract and inner organs, they may also protect LDLs against oxidation and inhibit platelet aggregation and therefore prevent cardiovascular diseases.

3-Butylidenephthalide
Catalog No: CFN99588

(Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(50) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM. It can induce a dose-dependent antinociceptive action in the hot-plate assay, it is also effective for controlling the pain provoked by chemical irritation at the doses of 10 and 31.6 mg/kg.

Senkyunolide H
Catalog No: CFN99595

Senkyunolide H in cnidium rhizome may be a prototype for an anti-atherosclerotic drug, it can reduce the metamorphose damage of the RBC caused by ConA, the aggregation of the RBC also could be alleviated by it.